Abstract
We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / pharmacokinetics
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Antifungal Agents / therapeutic use*
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Disease Models, Animal
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Fusarium / drug effects*
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Fusarium / isolation & purification
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Lung Diseases, Fungal / drug therapy*
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Lung Diseases, Fungal / pathology
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Mice
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Mice, Inbred BALB C
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Microbial Sensitivity Tests
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Neutropenia / complications
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Neutropenia / metabolism
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Opportunistic Infections
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Pentamidine / pharmacology
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Pentamidine / therapeutic use*
Substances
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Antifungal Agents
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Pentamidine