Abstract
Arginine enhanced the killing of Pseudomonas aeruginosa by ciprofloxacin and tobramycin under anaerobic, but not aerobic, growth conditions. Arginine or nitrate also enhanced the killing by these antibiotics in mature biofilms, reducing viable cell counts by a factor of 10 to 100 beyond that achieved by antibiotics alone.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anaerobiosis
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Anti-Bacterial Agents / pharmacology*
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Arginine / drug effects*
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Biofilms / drug effects*
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Drug Synergism
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Nitrates / pharmacology*
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / growth & development
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Pseudomonas aeruginosa / isolation & purification
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Tobramycin / administration & dosage
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Tobramycin / pharmacology
Substances
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Anti-Bacterial Agents
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Nitrates
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Arginine
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Tobramycin