Abstract
We studied the evolution of human immunodeficiency virus type 1 (HIV-1) in a cohort of long-term survivors infected with an attenuated strain of HIV-1 acquired from a single source. Although the cohort members experienced differing clinical courses, we demonstrate similar evolution of HIV-1 nef/long-terminal repeat (LTR) sequences, characterized by progressive sequence deletions tending toward a minimal nef/LTR structure that retains only sequence elements required for viral replication. The in vivo pathogenicity of attenuated HIV-1 is therefore dictated by viral and/or host factors other than those that impose a unidirectional selection pressure on the nef/LTR region of the HIV-1 genome.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological
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Aged
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Cohort Studies
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Female
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Gene Deletion
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Gene Products, nef / genetics*
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HIV Infections / virology*
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HIV Long Terminal Repeat / genetics*
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HIV-1 / genetics*
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HIV-1 / physiology
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Sequence Analysis
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nef Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, nef
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nef Gene Products, Human Immunodeficiency Virus
Associated data
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GENBANK/DQ287272
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GENBANK/DQ287273
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GENBANK/DQ287274
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GENBANK/DQ287275
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