Abstract
Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-Myb is activated are complex and involve truncations, point mutations, and fusion or coexpression with other proteins.
MeSH terms
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Animals
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Cell Differentiation / genetics
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Cell Division / genetics
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Gene Expression Regulation / physiology
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Hematopoietic Stem Cells / cytology*
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Humans
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Oncogene Proteins v-myb
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Proto-Oncogene Proteins / chemistry
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Proto-Oncogene Proteins / physiology*
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Proto-Oncogene Proteins c-myb
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Retroviridae Proteins, Oncogenic / chemistry
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Retroviridae Proteins, Oncogenic / physiology*
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Transcription Factors / chemistry
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Transcription Factors / physiology*
Substances
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Oncogene Proteins v-myb
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-myb
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Retroviridae Proteins, Oncogenic
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Transcription Factors