Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells

Curr Opin Genet Dev. 1992 Apr;2(2):249-55. doi: 10.1016/s0959-437x(05)80281-3.

Abstract

Myb is a transcriptional activator protein with repeated helix-turn-helix DNA-binding motifs distantly related to the homeodomain. In hematopoiesis, c-myb appears to control both cell proliferation and differentiation. The mechanisms by which the leukemogenic potential of c-Myb is activated are complex and involve truncations, point mutations, and fusion or coexpression with other proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Cell Division / genetics
  • Gene Expression Regulation / physiology
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Oncogene Proteins v-myb
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-myb
  • Retroviridae Proteins, Oncogenic / chemistry
  • Retroviridae Proteins, Oncogenic / physiology*
  • Transcription Factors / chemistry
  • Transcription Factors / physiology*

Substances

  • Oncogene Proteins v-myb
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myb
  • Retroviridae Proteins, Oncogenic
  • Transcription Factors