Abstract
We examined the findings from single-fiber electromyography in extensor digitorum communis (EDC) and orbicularis oculi (OOc) in 13 myasthenia gravis (MG) patients with muscle-specific kinase antibodies (MuSK-MG) and 12 MG patients with acetylcholine receptor antibodies (AChR-MG) with similar clinical scores. More than 70% of AChR-MG patients had abnormal jitter in both EDC and OOc, but the majority of MuSK-MG patients had normal jitter in EDC despite abnormal jitter in OOc. These findings demonstrate clear differences between the neurophysiology of MuSK-MG and AChR-MG.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism
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Antibodies / analysis
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Disability Evaluation
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Electromyography
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Electrophysiology
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Extremities / innervation
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Facial Muscles / innervation
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Facial Muscles / physiology*
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Humans
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Muscle Fibers, Skeletal / physiology*
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Muscle, Skeletal / innervation
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Muscle, Skeletal / physiology*
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Myasthenia Gravis / immunology
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Myasthenia Gravis / metabolism*
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Neurologic Examination
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Receptor Protein-Tyrosine Kinases / metabolism*
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Receptors, Cholinergic / immunology
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Receptors, Cholinergic / metabolism*
Substances
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Antibodies
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Receptors, Cholinergic
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MUSK protein, human
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Receptor Protein-Tyrosine Kinases
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Acetylcholinesterase