Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

FEBS Lett. 1976 Dec 31;72(2):323-6. doi: 10.1016/0014-5793(76)80996-9.
No abstract available

MeSH terms

  • Animals
  • Anticholesteremic Agents / pharmacology*
  • Enzyme Activation / drug effects
  • Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent / chemistry*
  • Lovastatin / analogs & derivatives*
  • Lovastatin / chemistry
  • Lovastatin / pharmacology
  • Microsomes, Liver / enzymology*
  • Molecular Structure
  • Naphthols / chemistry
  • Naphthols / pharmacology*
  • Penicillium / chemistry*
  • Rats

Substances

  • Anticholesteremic Agents
  • Naphthols
  • mevastatin
  • ML 236A
  • Lovastatin
  • Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent