Abstract
A few substituted piperazinylphenyloxazolidinone compounds 6-13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been synthesized and evaluated for their antibacterial activity in Gram-positive bacteria. A few compounds showed superior in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes than linezolid and eperezolid.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Enterococcus faecalis / drug effects
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Enterococcus faecalis / growth & development
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / growth & development
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Microbial Sensitivity Tests
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Oxazolidinones* / chemical synthesis
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Oxazolidinones* / chemistry
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Oxazolidinones* / pharmacology
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Piperazine
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Piperazines / chemistry*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / growth & development
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Streptococcus pyogenes / drug effects
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Streptococcus pyogenes / growth & development
Substances
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Anti-Bacterial Agents
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Oxazolidinones
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Piperazines
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Piperazine