Gene-dosage mapping of 30 DNA markers on chromosome 21

Genomics. 1992 Jul;13(3):887-9. doi: 10.1016/0888-7543(92)90177-t.

Abstract

Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aneuploidy
  • Chromosomes, Human, Pair 21*
  • DNA / genetics*
  • Gene Rearrangement
  • Genetic Markers*
  • Humans
  • Hybrid Cells
  • Multigene Family
  • Trisomy

Substances

  • Genetic Markers
  • DNA