Cytotoxic lignans from the stems of Helicteres hirsuta collected in Indonesia

Phytother Res. 2006 Jan;20(1):62-5. doi: 10.1002/ptr.1806.

Abstract

Cytotoxicity-guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (+/-)-pinoresinol, (+/-)-medioresinol, (+/-)-syringaresinol, (-)-boehmenan, (-)-boehmenan H and (+/-)-trans-dihydrodiconiferyl alcohol. Of these isolates, (+/-)-pinoresinol exhibited potent cytotoxic effects when evaluated against a small panel of cancer cell lines.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line
  • Cell Line, Tumor
  • Chromatography, High Pressure Liquid / methods
  • Humans
  • Indonesia
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / toxicity*
  • Malvaceae / chemistry*
  • Mass Spectrometry / methods
  • Molecular Structure
  • Plant Stems / chemistry
  • Toxicity Tests

Substances

  • Antineoplastic Agents, Phytogenic
  • Lignans