[Role of lipid peroxides in the pathogenesis of arteriosclerosis. Detoxication of lipid peroxides by the glutathione-peroxidase system in the aorta]

V Z Lankin; S M Gurevich; N V Kotelevtseva; A K Tikhaze; E N Gerasimova

[Role of lipid peroxides in the pathogenesis of arteriosclerosis. Detoxication of lipid peroxides by the glutathione-peroxidase system in the aorta]

Vopr Med Khim. 1976 May-Jun;22(3):392-5.

[Article in Russian]

Authors

V Z Lankin, S M Gurevich, N V Kotelevtseva, A K Tikhaze, E N Gerasimova

PMID: 16399

Abstract

In aorta of intact rabbits the high activity of glutathione-peroxidase, which detoxicates lipoperoxides, was observed. In aorta of animals with pronounced experimental atheromatosis the enzyme activity did not distinctly differ from the control values. The animals with high initial content of glutathione-peroxidase in aorta were shown to be less subjected to the impairment in alimentary atherosclerosis.

Publication types

English Abstract

MeSH terms

Animals
Aorta / enzymology*
Aortic Diseases / etiology*
Aortic Diseases / metabolism
Arteriosclerosis / etiology*
Arteriosclerosis / metabolism
Biotransformation
Diet, Atherogenic
Erythrocytes / enzymology
Glutathione Peroxidase / metabolism*
Lipid Metabolism*
Male
NADP / metabolism
Oxidation-Reduction
Peroxidases / metabolism*
Peroxides / metabolism*
Rabbits

Substances

Peroxides
NADP
Peroxidases
Glutathione Peroxidase