IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Cancer Lett. 2006 Jan 18;231(2):309-13. doi: 10.1016/j.canlet.2005.02.023.

Abstract

To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • Capsid / immunology*
  • Capsid Proteins / immunology*
  • Case-Control Studies
  • Cohort Studies
  • DNA, Viral / analysis
  • DNA, Viral / genetics
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Neoplasm Regression, Spontaneous*
  • Oncogene Proteins, Viral / immunology
  • Papillomaviridae / classification
  • Papillomaviridae / immunology
  • Papillomavirus Infections / immunology*
  • Papillomavirus Infections / virology
  • Uterine Cervical Dysplasia / immunology*
  • Uterine Cervical Dysplasia / virology
  • Uterine Cervical Neoplasms / immunology*
  • Uterine Cervical Neoplasms / virology
  • Viral Proteins

Substances

  • Antibodies, Viral
  • Capsid Proteins
  • DNA, Viral
  • Immunoglobulin G
  • Oncogene Proteins, Viral
  • Viral Proteins
  • L1 protein, Human papillomavirus type 6
  • L1 protein, Human papillomavirus type 16