Effect of the amount of internal standard on the precision of an analytical method

J Clin Pharmacol. 1992 Jul;32(7):676-7. doi: 10.1002/j.1552-4604.1992.tb05781.x.

Abstract

In an earlier published paper, a confidence interval approach was used to show that the use of a large amount of internal standard (relative to the analyte) would adversely affect the precision of the analytical method. However, the confidence intervals were not calculated correctly. The authors recalculated the confidence intervals and found that there is no effect on the precision as measured by the confidence intervals.

Publication types

  • Comparative Study

MeSH terms

  • Chemistry Techniques, Analytical / methods
  • Chemistry Techniques, Analytical / standards*
  • Confidence Intervals
  • Humans
  • Pharmaceutical Preparations / analysis
  • Regression Analysis
  • Reproducibility of Results

Substances

  • Pharmaceutical Preparations