Abstract
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
Publication types
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Clinical Trial
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Down-Regulation / drug effects
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Down-Regulation / physiology
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Female
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Hematopoietic Stem Cell Transplantation / methods*
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Humans
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Male
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Melphalan / therapeutic use*
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Middle Aged
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Myeloablative Agonists / therapeutic use*
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POEMS Syndrome / physiopathology
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POEMS Syndrome / therapy*
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Peripheral Nervous System Diseases / drug therapy
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Peripheral Nervous System Diseases / etiology
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Peripheral Nervous System Diseases / physiopathology
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Plasmacytoma / complications
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Plasmacytoma / drug therapy
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Plasmacytoma / metabolism
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Transplantation, Autologous
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Treatment Outcome
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Vascular Endothelial Growth Factor A / blood
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Myeloablative Agonists
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Vascular Endothelial Growth Factor A
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Melphalan