Abstract
In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Tissue Transplantation
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Cell Movement
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Cell Polarity
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Cerebral Ventricles / cytology
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Cerebral Ventricles / physiology
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Cerebrospinal Fluid / physiology*
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Choroid Plexus / metabolism
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Cilia / physiology
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Ependyma / cytology
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Ependyma / physiology*
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Epithelial Cells / physiology
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Intercellular Signaling Peptides and Proteins
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Mice
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Nerve Tissue Proteins / cerebrospinal fluid
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Neurons / cytology
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Neurons / physiology*
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Olfactory Bulb / cytology
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Olfactory Bulb / physiology
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Recombinant Fusion Proteins / cerebrospinal fluid
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Slit Homolog 2 Protein
Substances
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Intercellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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Recombinant Fusion Proteins
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Slit Homolog 2 Protein