Abstract
p-Aminobenzoic acid (p-ABA) derivatives were evaluated as acetylcholinesterase inhibitors (AChEIs). Finding a correlation between AChE activity with the partition coefficient (log P) and the highest occupied molecular orbital (HOMO) energy of the compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoic Acid / chemistry*
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Benzoic Acid / pharmacology*
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Brain / drug effects
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Brain / enzymology
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Cholinesterase Inhibitors / chemistry*
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Cholinesterase Inhibitors / pharmacology*
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Cholinesterases / metabolism*
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Male
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Mice
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Molecular Structure
Substances
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Cholinesterase Inhibitors
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Benzoic Acid
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Cholinesterases