Abstract
CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism
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Brain / physiology
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Brain / physiopathology
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Cyclic AMP Response Element-Binding Protein / biosynthesis*
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DNA Primers
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Hippocampus / physiology*
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Hippocampus / physiopathology
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Hypoxia-Inducible Factor 1 / biosynthesis
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Ischemic Attack, Transient / metabolism*
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Polymerase Chain Reaction
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Rats
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Repressor Proteins / biosynthesis*
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Trans-Activators / biosynthesis*
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Transcription, Genetic
Substances
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Cyclic AMP Response Element-Binding Protein
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DNA Primers
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Hypoxia-Inducible Factor 1
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Repressor Proteins
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Trans-Activators