Abstract
A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product was fully elucidated by various spectroscopic techniques, and the mechanism of generating such novel metabolite is also discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / metabolism*
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Artemisinins / chemistry
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Artemisinins / metabolism*
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Biotransformation
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Sesquiterpenes / chemistry
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Sesquiterpenes / metabolism*
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Spectrophotometry, Infrared
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Streptomyces griseus / metabolism*
Substances
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Anti-Infective Agents
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Artemisinins
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Sesquiterpenes
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artemisinin