Four new epoxy taxanes from needles of Taxus cuspidata (Taxaceae)

Nat Prod Res. 2006 Feb;20(2):173-9. doi: 10.1080/14786410500049426.

Abstract

Four new epoxy taxoids were isolated from the needles of Taxus cuspidata. Their structures were established as 2a,9a-diacetoxy-5a-cinnamoyloxy-11,12-epoxy-10ss-hydroxytax-4(20)-en-13-one (1), 2a,10ss-diacetoxy-5a-cinnamoyloxy-11,12-epoxy-9a-hydroxytax-4(20)-en-13-one (2), 2a,9a-diacetoxy-11,12-epoxy-10ss,20-dihydroxytax-4-en-13-one (3) and 2a,10ss-diacetoxy-11,12-epoxy-9a,20-dihydroxytax-4-en-13-one (4) on the basis of spectral analysis including 1H-NMR, 13C-NMR, 1H-1H-COSY, HSQC, HMBC and HRFABMS. Compounds 3 and 4 are the first example of 11,12-epoxy taxoids with C-4 double bond found in T. cuspidata.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Leaves / chemistry*
  • Taxoids / chemistry
  • Taxoids / isolation & purification*
  • Taxus / chemistry*

Substances

  • Taxoids