Hyperglycosylated ferritin in sera of HIV-1-infected patients treated with highly active antiretroviral therapy

AIDS. 2006 Feb 14;20(3):457-9. doi: 10.1097/01.aids.0000199824.26618.62.

Abstract

A study was conducted to determine the relationship between ferritin and glycosylated isoforms of ferritin and insulin resistance in 69 HIV-infected men receiving HAART. Ferritin levels were significantly correlated with aspartate aminotransferase, alanine aminotransferase, bilirubin and with insulin resistance. The ferritin isoelectric focusing patterns of five insulin-resistant HIV-infected patients under HAART showed large amounts of hyperglycosylated isoforms, which was not found in 56 control subjects and 46 untreated HIV-1-infected patients.

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active*
  • Ferritins / metabolism*
  • Glycosylation
  • HIV Infections / blood
  • HIV Infections / drug therapy*
  • HIV-1*
  • Humans
  • Insulin Resistance
  • Isoelectric Focusing
  • Liver Diseases / metabolism*
  • Liver Diseases / virology
  • Male
  • Metabolic Syndrome / metabolism
  • Metabolic Syndrome / virology

Substances

  • Ferritins