Targeting vascular endothelial growth factor in angina therapy

Expert Opin Ther Targets. 2006 Feb;10(1):5-14. doi: 10.1517/14728222.10.1.5.

Abstract

Despite tremendous success of growth factor therapy in animal models, clinical trials have demonstrated minimal success. Vascular endothelial growth factors are perhaps the most potent inducers of angiogenesis in these animal models. This review outlines the biology of vascular endothelial growth factors in the context of myocardial angiogenesis with an emphasis on its effects on the endothelium. It also provides an overview of delivery strategies and summarises the preclinical and clinical evidence relating to exogenous growth factor delivery for myocardial angiogenesis with an emphasis on the key future challenges.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angina Pectoris / drug therapy*
  • Angina Pectoris / genetics
  • Angina Pectoris / physiopathology
  • Animals
  • Cardiovascular Agents / administration & dosage*
  • Drug Delivery Systems / methods*
  • Humans
  • Vascular Endothelial Growth Factor A / metabolism*
  • Vascular Endothelial Growth Factor A / physiology

Substances

  • Cardiovascular Agents
  • Vascular Endothelial Growth Factor A