Among 530 consecutive patients hospitalized for acute hepatitis cytomegalovirus infection was diagnosed in 5 (0.9%). In 2 cases the infection was due to blood transfusion. The course of the disease was Got essentially different from hepatitis A, B, or non-A, non-B, however, clinical and biochemical manifestations of cholestasis were common. All biochemical abnormalities returned to normal within few weeks. In conclusion, it seems that cytomegalovirus is a rare cause of clinically overt hepatitis and its course is often cholestatic.