Synthesis of [18F]fluoro-labeled progestins for PET

T J de Groot; A Verhagen; P H Elsinga; W Vaalburg

doi:10.1016/0883-2889(91)90108-d

Synthesis of [18F]fluoro-labeled progestins for PET

Int J Rad Appl Instrum A. 1991;42(5):471-4. doi: 10.1016/0883-2889(91)90108-d.

Authors

T J de Groot¹, A Verhagen, P H Elsinga, W Vaalburg

Affiliation

¹ PET Center, University of Groningen, The Netherlands.

PMID: 1646193
DOI: 10.1016/0883-2889(91)90108-d

Abstract

The synthesis of 21-[18F]fluoro-16 alpha-methyl-19-norprogesterone, 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone, 21-[18F]fluoro-16 alpha-methylprogesterone and 21-[18F]fluoro-16 alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.

MeSH terms

Fluorine Radioisotopes*
Isotope Labeling / methods*
Progesterone / analogs & derivatives*
Progesterone / chemical synthesis
Tomography, Emission-Computed*

Substances

Fluorine Radioisotopes
Progesterone