Abstract
We have synthesized several new quinophenoxazine analogues and tested their cytotoxicity activities. The results showed that the compounds, 4a and 4b, possessing phenyl ring in the structure have almost same pharmacological capacity with A-62176. This finding suggests that the phenyl ring portion is important to this series of compounds for the activity expression.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology*
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Drug Screening Assays, Antitumor
-
Humans
-
Indicators and Reagents
-
Magnetic Resonance Spectroscopy
-
Oxazines / chemical synthesis*
-
Oxazines / pharmacology
Substances
-
Antineoplastic Agents
-
Indicators and Reagents
-
Oxazines