PLA2 inhibitory activity of marine sesterterpenoids cladocorans, their diastereomers and analogues

Chem Pharm Bull (Tokyo). 2006 Feb;54(2):268-70. doi: 10.1248/cpb.54.268.

Abstract

Inhibition of secretory phospholipase A(2) (sPLA(2)) by cladocorans A and B and their diastereomers almost equaled that of manoalide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / pharmacology
  • Animals
  • Anthozoa / chemistry*
  • Bee Venoms / enzymology
  • Bees
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Phosphodiesterase Inhibitors*
  • Phospholipases A / antagonists & inhibitors*
  • Phospholipases A2
  • Stereoisomerism
  • Terpenes / pharmacology

Substances

  • Bee Venoms
  • Indicators and Reagents
  • Phosphodiesterase Inhibitors
  • Terpenes
  • cladocoran A
  • manoalide
  • Phospholipases A
  • Phospholipases A2
  • dysidiolide
  • 4-Butyrolactone