bcr-abl-positive T-cell acute lymphoblastic leukemia associated with parvovirus B19 infection

J Pediatr Hematol Oncol. 2006 Feb;28(2):98-9. doi: 10.1097/01.mph.0000199589.21797.dd.

Abstract

The authors report an unusual presentation of a Philadelphia chromosome-positive acute lymphoblastic leukemia with two unusual features: a bcr-abl fusion mRNA coding for p210 protein and a T-cell immunophenotype. The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection. Management consisted of supportive therapy, followed by chemotherapy for T-cell acute lymphoblastic leukemia and stem cell transplantation. He died 8 months after transplant due to idiopathic pneumonia syndrome, but without evidence of relapsed disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asparaginase / administration & dosage
  • Bone Marrow / virology
  • Cerebral Hemorrhage / etiology
  • Combined Modality Therapy
  • Disseminated Intravascular Coagulation / etiology
  • Fatal Outcome
  • Fusion Proteins, bcr-abl / blood
  • Genes, abl
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / drug therapy
  • Leukemia-Lymphoma, Adult T-Cell / etiology*
  • Leukemia-Lymphoma, Adult T-Cell / genetics
  • Leukemia-Lymphoma, Adult T-Cell / therapy
  • Male
  • Methotrexate / administration & dosage
  • Multiple Organ Failure / etiology
  • Neoplasm Proteins / blood
  • Pancytopenia / etiology
  • Parvoviridae Infections / complications*
  • Parvovirus B19, Human / isolation & purification
  • Parvovirus B19, Human / pathogenicity*
  • Philadelphia Chromosome*
  • Pneumonia / etiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Prednisone / administration & dosage
  • Preleukemia / complications*
  • Shock, Septic / etiology
  • Staphylococcal Infections / complications
  • Vincristine / administration & dosage

Substances

  • Neoplasm Proteins
  • Vincristine
  • Fusion Proteins, bcr-abl
  • Asparaginase
  • Prednisone
  • Methotrexate