Substituted coumarins as potent 5-lipoxygenase inhibitors

Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. doi: 10.1016/j.bmcl.2006.01.085. Epub 2006 Feb 7.

Abstract

Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.

MeSH terms

  • Coumarins / chemical synthesis
  • Coumarins / chemistry
  • Coumarins / pharmacology*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Lipoxygenase Inhibitors*
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Coumarins
  • Enzyme Inhibitors
  • Lipoxygenase Inhibitors