Abstract
Genera of the order Mucorales (Rhizopus, Mucor, Rhizomucor, Absidia, Apophysomyces, Cunninghamella, and Saksenaea) cause an angioinvasive infection called zygomycosis. Mortality rates can approach 100% depending on the patient's underlying disease and form of zygomycosis. We report here on the unusual case of a patient with acute myelogenous leukemia and zygomycosis unresponsive to monotherapy with liposomal amphotericin B, who responded favorably following the addition of the echinocandin caspofungin acetate.
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / therapeutic use*
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Antifungal Agents / administration & dosage
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Antifungal Agents / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Caspofungin
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Combined Modality Therapy
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Cytarabine / administration & dosage
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Cytarabine / adverse effects
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Debridement
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Diplopia / etiology
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Drug Therapy, Combination
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Echinocandins
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Humans
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Idarubicin / administration & dosage
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Idarubicin / adverse effects
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Immunocompromised Host
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Leukemia, Myeloid, Acute / complications
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Leukemia, Myeloid, Acute / drug therapy
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Lipopeptides
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Male
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Middle Aged
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Mitoxantrone / administration & dosage
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Mitoxantrone / adverse effects
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Opportunistic Infections / drug therapy*
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Opportunistic Infections / etiology
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Orbital Diseases / drug therapy*
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Orbital Diseases / etiology
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Orbital Diseases / microbiology
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Orbital Diseases / surgery
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Peptides, Cyclic / administration & dosage
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Peptides, Cyclic / therapeutic use*
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Sinusitis / drug therapy*
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Sinusitis / etiology
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Sinusitis / microbiology
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Sinusitis / surgery
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Zygomycosis / drug therapy*
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Zygomycosis / etiology
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Zygomycosis / surgery
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides, Cyclic
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liposomal amphotericin B
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Cytarabine
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Amphotericin B
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Mitoxantrone
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Caspofungin
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Idarubicin