Abstract
The tissue microarray technique (TMA) represents a powerful diagnostic "high-throughput" tool to analyse DNA/RNA or protein alterations in large patient cohorts in a time and cost effective way. This review focuses on the clinical application of TMA in renal cell carcinoma in modern "translational" medicine--"from bench to bedside". In particular, the advantages of TMA for diagnosis, prognosis and decisions for therapy will be considered in relation to renal cell cancer.
MeSH terms
-
Carcinoma, Renal Cell / diagnosis*
-
Carcinoma, Renal Cell / genetics*
-
Carcinoma, Renal Cell / mortality
-
Carcinoma, Renal Cell / pathology
-
Cathepsin D / genetics
-
Gene Expression Regulation, Neoplastic / physiology
-
Genetic Markers / genetics*
-
Humans
-
Kidney / pathology
-
Kidney Neoplasms / diagnosis*
-
Kidney Neoplasms / genetics*
-
Kidney Neoplasms / mortality
-
Kidney Neoplasms / pathology
-
Neoplasm Proteins / genetics*
-
Oligonucleotide Array Sequence Analysis
-
Paraffin Embedding
-
Predictive Value of Tests
-
Prognosis
-
Protein Array Analysis / methods*
-
Survival Analysis
Substances
-
Genetic Markers
-
Neoplasm Proteins
-
Cathepsin D