A case of peritonitis caused by Rhizopus microsporus

Mycoses. 2006 Mar;49(2):139-42. doi: 10.1111/j.1439-0507.2006.01190.x.

Abstract

We report a case of a 62-year-old female patient who developed peritonitis after receiving a renal transplant. Candida glabrata was detected and treated with voriconazole. As the patient did not improve under therapy, laparotomy was performed. Mould-like plaques were found on the peritoneum. Using culture as well as pan-fungal polymerase chain reaction (PCR) followed by DNA microarray hybridisation of the amplicon, the causative agent was identified as Rhizopus microsporus. Despite aggressive surgical treatment, intravenous therapy with amphotericin B and topical administration of Lavasept (polyhexamethylenbiguanide), the patient died.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Amphotericin B / administration & dosage
  • Biguanides / administration & dosage
  • Candida glabrata / isolation & purification
  • DNA, Fungal / analysis
  • DNA, Fungal / genetics
  • Fatal Outcome
  • Female
  • Humans
  • Kidney Transplantation
  • Laparoscopy
  • Middle Aged
  • Mucormycosis / drug therapy
  • Mucormycosis / microbiology*
  • Mucormycosis / surgery
  • Nucleic Acid Hybridization
  • Oligonucleotide Array Sequence Analysis
  • Peritonitis / drug therapy
  • Peritonitis / microbiology*
  • Peritonitis / surgery
  • Polymerase Chain Reaction
  • Renal Insufficiency, Chronic / complications*
  • Rhizopus / genetics
  • Rhizopus / isolation & purification*

Substances

  • Biguanides
  • DNA, Fungal
  • Amphotericin B