MRI compatible electrodes for the induction of amygdala kindling in rats

Bianca Jupp; John P Williams; Yasvir A Tesiram; Milosh Vosmansky; Terence J O'Brien

doi:10.1016/j.jneumeth.2005.12.024

MRI compatible electrodes for the induction of amygdala kindling in rats

J Neurosci Methods. 2006 Jul 15;155(1):72-6. doi: 10.1016/j.jneumeth.2005.12.024. Epub 2006 Feb 8.

Authors

Bianca Jupp¹, John P Williams, Yasvir A Tesiram, Milosh Vosmansky, Terence J O'Brien

Affiliation

¹ The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia.

PMID: 16466802
DOI: 10.1016/j.jneumeth.2005.12.024

Abstract

The rat electrical kindling model has been widely utilized in epilepsy research. This study aimed to identify the optimum "MRI compatible" bipolar stimulating and recording electrodes to enable serial MRI acquisition in this model. Two types of custom-made electrodes (gold and carbon) were compared with commercial platinum-iridium alloy electrodes for suitability based on size, effect on image quality and kindling induction. The custom-made gold electrodes, based on these parameters, were found to be most suitable. These electrodes enable the study of epileptogenesis utilizing MRI in this model of temporal lobe epilepsy (TLE).

Publication types

Comparative Study

MeSH terms

Amygdala / pathology
Amygdala / physiopathology*
Animals
Carbon / standards
Disease Models, Animal
Electric Stimulation / instrumentation
Electric Stimulation / methods
Electrodes, Implanted / standards
Electrodes, Implanted / trends
Electroencephalography / instrumentation*
Electroencephalography / methods
Epilepsy / diagnosis
Epilepsy / physiopathology*
Gold / standards
Iridium / standards
Kindling, Neurologic / physiology*
Magnetic Resonance Imaging / methods*
Magnetic Resonance Imaging / standards
Male
Neurophysiology / instrumentation*
Neurophysiology / methods
Platinum / standards
Rats
Rats, Wistar

Substances

Iridium
Platinum
Carbon
Gold