The aim of the present research was to investigate early impairments of central nervous system in subjects exposed to a low toxic level of industrial solvents for several years. Therefore a group of fifteen shoe-workers, with symptoms of minimal polyneuropathy, and a group of twenty, sex and age matched, healthy volunteers were selected for multimodal evoked potentials studies. The statistical analysis revealed a decrease of VEP and SEP amplitudes as well as a significant higher percentage of cases with BAEP V/I ratio between 0.5 and 1 among patients. The wrist-Erb's point conduction velocity was, also, found lowered in them. In accordance with the experimental results, the systematic employment of multimodal evoked potentials is proposed for screening the subjects exposed to neurotoxic influence of industrial solvents.