Evaluation of occupational exposure to N-nitrosamines in a rubber-manufacturing industry

J Occup Environ Med. 2006 Feb;48(2):195-8. doi: 10.1097/01.jom.0000200938.96781.64.

Abstract

Objective: We sought to determine volatile N-nitrosamines levels in the air of a rubber-manufacturing industry and to measure urinary N-nitrosamines concentrations in exposed workers.

Methods: Personal monitoring of 34 workers was performed by sampling nine airborne N-nitrosamines in four factories that manufactured rubber drive belts for automotive engines. Urinary N-nitrosamine levels were determined in all workers and in a control group of 26 subjects. Analyses were conducted by capillary gas chromatography-thermal energy analyzer.

Results: Airborne and urinary N-nitrosamines levels were very low and, in most cases, below the limit of detection (0.06 microg/m and 0.1 microg/L, respectively).

Conclusions: Although airborne and urinary N-nitrosamines levels were found to be very low, exposed workers should still be monitored constantly because some of these substances are known to be genotoxic and carcinogenic.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Air Pollutants, Occupational / analysis*
  • Air Pollutants, Occupational / urine
  • Case-Control Studies
  • Female
  • Humans
  • Italy
  • Male
  • Nitrosamines / analysis*
  • Nitrosamines / urine
  • Occupational Exposure / analysis*
  • Rubber*

Substances

  • Air Pollutants, Occupational
  • Nitrosamines
  • Rubber