STAT3 in immune responses and inflammatory bowel diseases

Xin Yuan Fu

doi:10.1038/sj.cr.7310029

STAT3 in immune responses and inflammatory bowel diseases

Cell Res. 2006 Feb;16(2):214-9. doi: 10.1038/sj.cr.7310029.

Author

Xin Yuan Fu¹

Affiliation

¹ Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, 635 Barnhill Drive, MS 420, Indianapolis, IN 46202-5120, USA. [email protected]

PMID: 16474436
DOI: 10.1038/sj.cr.7310029

Abstract

STAT3 has been known as a mediator for gene expression induced by many important cytokines. Recent studies have suggested that STAT3 has important functions in regulation of both innate and adaptive immunity. Loss of STAT3 in immune cells caused severe inflammation in response to pathogens. This review discusses the recent progress and suggests directions for the future research on this interesting molecule.

Publication types

Review

MeSH terms

Animals
Cytokines / immunology
Dendritic Cells / immunology
Humans
Immune System / physiology*
Inflammatory Bowel Diseases / immunology*
Interleukin-10 / genetics
Interleukin-10 / immunology
Nod2 Signaling Adaptor Protein / genetics
Nod2 Signaling Adaptor Protein / immunology
STAT3 Transcription Factor / immunology*
T-Lymphocytes, Regulatory / immunology

Substances

Cytokines
NOD2 protein, human
Nod2 Signaling Adaptor Protein
STAT3 Transcription Factor
Interleukin-10