Abstract
Bullous pemphigoid, the most frequent bullous autoimmune dermatosis of the adult, typically presents as disseminated tense blisters on normal or erythematous skin. The diagnosis can be confirmed by direct and indirect immunofluorescence, the detection of circulating autoantibodies against the basement membrane proteins collagen XVII/BP180 and BP230, and histopathology. Autoantibody reactivity against collagen XVII can be measured by ELISA and correlates with disease activity. The ELISA therefore provides a useful tool for monitoring disease activity. Treatment of bullous pemphigoid usually consists of topical and / or systemic steroids in combination with immunosuppressive agents. The intensity of skin involvement and the concurrent diseases and medications of the patient must be considered when selecting a certain treatment. Interdisciplinary cooperation between general practitioners, internists and other specialists facilitates the optimal adaptation of the medication and the early discovery of potential side effects.
MeSH terms
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Adrenal Cortex Hormones / administration & dosage
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Adrenal Cortex Hormones / adverse effects
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Aged
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / therapeutic use
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Autoantibodies / analysis
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Azathioprine / administration & dosage
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Azathioprine / adverse effects
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Azathioprine / therapeutic use
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Biopsy
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Blotting, Western
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Child
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Clobetasol / administration & dosage
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Clobetasol / adverse effects
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Clobetasol / analogs & derivatives
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Clobetasol / therapeutic use
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects
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Cyclophosphamide / therapeutic use
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Dapsone / administration & dosage
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Dapsone / adverse effects
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Dapsone / therapeutic use
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Dermatologic Agents / administration & dosage
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Dermatologic Agents / adverse effects
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Dermatologic Agents / therapeutic use
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Diagnosis, Differential
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Drug Therapy, Combination
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Enzyme-Linked Immunosorbent Assay
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Female
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Fluorescent Antibody Technique, Direct
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Fluorescent Antibody Technique, Indirect
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Humans
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Immunoglobulins, Intravenous / administration & dosage
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Immunoglobulins, Intravenous / adverse effects
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Immunoglobulins, Intravenous / therapeutic use
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use
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Male
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Mycophenolic Acid / administration & dosage
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Mycophenolic Acid / adverse effects
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Mycophenolic Acid / analogs & derivatives
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Mycophenolic Acid / therapeutic use
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Niacinamide / administration & dosage
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Niacinamide / adverse effects
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Niacinamide / therapeutic use
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Pemphigoid, Bullous* / classification
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Pemphigoid, Bullous* / diagnosis
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Pemphigoid, Bullous* / drug therapy
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Pemphigoid, Bullous* / etiology
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Pemphigoid, Bullous* / immunology
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Pemphigoid, Bullous* / pathology
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Pregnancy
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Skin / pathology
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Vitamin B Complex / administration & dosage
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Vitamin B Complex / adverse effects
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Vitamin B Complex / therapeutic use
Substances
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Adrenal Cortex Hormones
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Anti-Inflammatory Agents
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Autoantibodies
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Dermatologic Agents
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Immunoglobulins, Intravenous
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Immunosuppressive Agents
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Vitamin B Complex
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Niacinamide
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Cyclophosphamide
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Dapsone
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Clobetasol
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Mycophenolic Acid
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Azathioprine