Comparative study of characteristics and disease management between subjects with frequent and occasional gastro-oesophageal reflux symptoms

Aliment Pharmacol Ther. 2006 Mar 1;23(5):607-16. doi: 10.1111/j.1365-2036.2006.02811.x.

Abstract

Background: Little is known about the distinctive characteristics of subjects with frequent (at least weekly) and occasional gastro-oesophageal reflux symptoms.

Aim: To compare the characteristics and disease management of subjects complaining of at least weekly and less frequent gastro-oesophageal reflux symptoms.

Methods: Population-based postal survey carried out in France in 2003 among a representative sample of 8000 subjects.

Results: The prevalence of frequent and occasional gastro-oesophageal reflux symptoms was 7.8% and 23.4%, respectively. Compared to subjects with occasional gastro-oesophageal reflux symptoms, those with frequent symptoms were older, suffered from more severe symptoms and felt greater impact on daily living, despite a slightly shorter duration of symptoms. These subjects more often sought medical advice. Most of them had treated the last episode of symptoms primarily with a proton-pump inhibitor and less often with antacids/alginates. The degree of treatment satisfaction was lower in subjects with frequent gastro-oesophageal reflux symptoms, in relation to a more frequently observed persistence of symptoms irrespective of the medication used except for proton-pump inhibitors.

Conclusions: This survey suggests that subjects complaining of frequent or occasional gastro-oesophageal reflux symptoms constitute two distinctive groups. Despite greater healthcare use, the former group shows a lower level of satisfaction with disease management. Nevertheless, a substantial subset of subjects with occasional symptoms also complained of impaired health-related quality of life and sought health care.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adult
  • Age Factors
  • Alginates / administration & dosage
  • Antacids / administration & dosage
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • France / epidemiology
  • Gastroesophageal Reflux / drug therapy*
  • Gastroesophageal Reflux / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Patient Acceptance of Health Care
  • Patient Satisfaction
  • Population Surveillance / methods
  • Prevalence
  • Proton Pump Inhibitors
  • Risk Factors
  • Severity of Illness Index
  • Time Factors

Substances

  • Alginates
  • Antacids
  • Proton Pump Inhibitors