Disseminate and fatal cytomegalovirus disease with thymitis in a naive HIV-patient after early initiation of HAART: immune restoration disease?

Sonia Gutiérrez; Silvia Alconchel; Ezequiel Ruiz-Mateos; Miguel Genebat; Alejandro Vallejo; Eduardo Lissen; Jorge Fernández-Alonso; Manuel Leal

doi:10.1016/j.jcv.2005.12.007

Disseminate and fatal cytomegalovirus disease with thymitis in a naive HIV-patient after early initiation of HAART: immune restoration disease?

J Clin Virol. 2006 May;36(1):13-6. doi: 10.1016/j.jcv.2005.12.007. Epub 2006 Feb 14.

Authors

Sonia Gutiérrez¹, Silvia Alconchel, Ezequiel Ruiz-Mateos, Miguel Genebat, Alejandro Vallejo, Eduardo Lissen, Jorge Fernández-Alonso, Manuel Leal

Affiliation

¹ Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain.

PMID: 16481214
DOI: 10.1016/j.jcv.2005.12.007

Abstract

We describe a naive HIV-infected patient who developed a Pneumocystis carinii pneumonia and disseminate and fatal cytomegalovirus disease within 3 months after initiation of HAART, suggesting due to coincidence in time, an immune restoration disease. We propose an alternative hypothesis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / immunology*
AIDS-Related Opportunistic Infections / virology
Adult
Antiretroviral Therapy, Highly Active*
CD4 Lymphocyte Count
Cytomegalovirus Infections / complications*
Fatal Outcome
Female
HIV Infections / complications*
HIV Infections / drug therapy*
Humans
Immunohistochemistry
Inclusion Bodies, Viral / metabolism
Lung / virology
Mediastinum / diagnostic imaging
Meningoencephalitis / pathology
Pneumonia, Pneumocystis / immunology*
RNA, Viral / blood
Radiography
Receptors, Antigen, T-Cell / analysis
Thymus Gland / virology
Time Factors
Viral Load

Substances

RNA, Viral
Receptors, Antigen, T-Cell