Using combined x-ray and MR imaging for prostate I-125 post-implant dosimetry: phantom validation and preliminary patient work

Phys Med Biol. 2006 Mar 7;51(5):1129-37. doi: 10.1088/0031-9155/51/5/005. Epub 2006 Feb 8.

Abstract

Post-implantation dosimetry is an important element of permanent prostate brachytherapy. This process relies on accurate localization of implanted seeds relative to the surrounding organs. Localization is commonly achieved using CT images, which provide suboptimal prostate delineation. On MR images, conversely, prostate visualization is excellent but seed localization is imprecise due to distortion and susceptibility artefacts. This paper presents a method based on fused MR and x-ray images acquired consecutively in a combined x-ray and MRI interventional suite. The method does not rely on any explicit registration step but on a combination of system calibration and tracking. A purpose-built phantom was imaged using MRI and x-rays, and the images were successfully registered. The same protocol was applied to three patients where combining soft tissue information from MRI with stereoscopic seed identification from x-ray imaging facilitated post-implant dosimetry. This technique has the potential to improve on dosimetry using either CT or MR alone.

MeSH terms

  • Aged
  • Brachytherapy*
  • Humans
  • Image Interpretation, Computer-Assisted
  • Iodine Radioisotopes / therapeutic use
  • Magnetic Resonance Imaging*
  • Male
  • Phantoms, Imaging
  • Prostate / diagnostic imaging
  • Prostate / pathology
  • Prostatic Neoplasms / diagnostic imaging
  • Prostatic Neoplasms / radiotherapy*
  • Radiography
  • Radiotherapy Planning, Computer-Assisted*

Substances

  • Iodine Radioisotopes