Abstract
Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Efficacy, safety, and tolerability of perindopril are well established in the treatment of hypertension and heart failure. Moreover, large morbidity-mortality trials, such as the EUROPA, PROGRESS, and PREAMI have shown that treatment with perindopril reduces morbidity and mortality and prevents cardiovascular disease in a large range of patients with vascular diseases, whether or not they are hypertensive. Thus, the outcomes of these and other trials support the concept of cardiovascular protective properties of angiotensin-converting enzyme inhibition with perindopril in addition to the obvious blood-pressure-lowering effect. Considering its properties and the clinical evidence on efficacy and tolerability that has been gathered, perindopril should be considered a first-line therapeutic agent in hypertension, heart failure and acute myocardial infarction and a tool of secondary prevention of coronary artery disease.
Publication types
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Comparative Study
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English Abstract
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Review
MeSH terms
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Aged
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage
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Angiotensin-Converting Enzyme Inhibitors / pharmacology
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
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Animals
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / pharmacology
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Antihypertensive Agents / therapeutic use*
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Cardiovascular Diseases / prevention & control*
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Diabetes Mellitus, Type 2 / drug therapy
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Female
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Follow-Up Studies
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Heart Failure / drug therapy
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Humans
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Hypertension / drug therapy*
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Indoles / administration & dosage
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Indoles / therapeutic use
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Male
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Middle Aged
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Multicenter Studies as Topic
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Myocardial Infarction / drug therapy*
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Myocardial Infarction / mortality
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Perindopril / administration & dosage
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Perindopril / pharmacology
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Perindopril / therapeutic use*
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Prospective Studies
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Ramipril / administration & dosage
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Ramipril / therapeutic use
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Randomized Controlled Trials as Topic
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Risk
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Risk Factors
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Stroke / prevention & control
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Time Factors
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Antihypertensive Agents
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Indoles
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trandolapril
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Ramipril
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Perindopril