Abstract
A flurry of articles on the structure of different domains of BRCA1 and BRCA2 have not only shed light on the biology of these proteins but have also raised hopes that these data could eventually be used to infer cancer association for a large number of inherited missense mutations whose effect on protein function is unclear.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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BRCA1 Protein / genetics
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BRCA1 Protein / physiology
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BRCA2 Protein / genetics
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BRCA2 Protein / physiology
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Breast Neoplasms / genetics
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Genes, BRCA1
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Genes, BRCA2
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Genetic Predisposition to Disease
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Humans
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Mutation, Missense*
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Neoplasms / genetics*
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Risk Assessment / methods
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Structure-Activity Relationship
Substances
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BRCA1 Protein
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BRCA2 Protein