Abstract
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry
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Animals
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Antigens, Neoplasm / chemistry*
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Antigens, Neoplasm / immunology
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Breast Neoplasms / immunology*
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Breast Neoplasms / therapy
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Cancer Vaccines / chemical synthesis*
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Cancer Vaccines / immunology
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Carbohydrate Sequence
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Cell Line, Tumor
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Female
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G(M2) Ganglioside / chemistry
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G(M2) Ganglioside / immunology
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Glycosides / chemistry
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Hemocyanins / chemistry
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Hemocyanins / immunology
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Humans
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Male
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Mice
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Molecular Sequence Data
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Oligosaccharides / chemistry
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Oligosaccharides / immunology
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Peptides / chemistry
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Peptides / immunology
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Prostatic Neoplasms / immunology*
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Prostatic Neoplasms / therapy
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Sialic Acids / chemistry
Substances
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Amino Acids
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Antigens, Neoplasm
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Cancer Vaccines
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Glycosides
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Oligosaccharides
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Peptides
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Sialic Acids
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G(M2) Ganglioside
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Hemocyanins
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keyhole-limpet hemocyanin