Abstract
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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Insulin / physiology*
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Phosphatidylinositol 3-Kinases / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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Receptor, Insulin / physiology*
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Signal Transduction*
Substances
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Insulin
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Phosphatidylinositol 3-Kinases
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Receptor, Insulin
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Proto-Oncogene Proteins c-akt