Abstract
A novel broad-spectrum aminoglycoside antibiotic, pyrankacin, has been prepared. In addition to the synthetic innovation in dideoxygenation and regioselective Staudinger reduction, we have obtained prominent antibacterial activity against several clinically important pathogens in the course of this work.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aminoglycosides* / chemical synthesis
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Aminoglycosides* / chemistry
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Aminoglycosides* / pharmacology
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Bacteria / drug effects*
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Escherichia coli / drug effects
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Klebsiella pneumoniae / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus aureus / drug effects
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Pyranmycin
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pyrankacin