Abstract
Efficient chemoenzymatic syntheses of iGb3 and Gb3 have been developed. Isoglobotrihexose and globotrihexose were enzymatically synthesized by a three-enzyme system in both solid and solution phases. Then iGb3 and Gb3 were chemically synthesized by coupling of the corresponding trisaccharides with lipid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbohydrate Sequence
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Galactosylceramides / chemistry
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Galactosylceramides / pharmacology
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Globosides / chemical synthesis*
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Globosides / metabolism
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Glycosylation
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Humans
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Killer Cells, Natural / drug effects
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Killer Cells, Natural / metabolism
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Mice
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Phosphoric Diester Hydrolases / metabolism*
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Trihexosylceramides / chemical synthesis*
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Trihexosylceramides / metabolism
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Trisaccharides
Substances
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Galactosylceramides
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Globosides
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Trihexosylceramides
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Trisaccharides
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globotrihexosylceramide
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isoglobotrihexosylceramide
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globotriaosylceramide
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Phosphoric Diester Hydrolases
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UDP-galactose hydrolase
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KRN 7000