Abstract
In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / pharmacology*
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Berberine / pharmacology*
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Candida albicans / drug effects
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Candida albicans / genetics*
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Candida albicans / isolation & purification
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Candidiasis / drug therapy
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Candidiasis / microbiology
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Drug Resistance, Fungal / drug effects
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Drug Resistance, Fungal / genetics*
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Drug Synergism
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Fluconazole / pharmacology*
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Humans
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In Vitro Techniques
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Microbial Sensitivity Tests
Substances
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Antifungal Agents
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Berberine
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Fluconazole