Abstract
Novel 5-X-substituted-2-azabicyclo[2.1.1]hexanes (X = 5-syn-Cl, -Br, -I, -Ph, -NHCOOR (R = Me, Bn, t-Bu), -CH2CH2COOMe and X = 5-anti-Br, -I, -Ph) were synthesized from the X = 5-syn-carboxy derivative. New 5-anti-X-2-azabicyclo[2.1.1]hexanes, X = NHCOOR (R = Me, Bn), were prepared stereoselectively from the X = 5-anti-carboxy substrate.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acids / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Esters
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Hexanes / chemical synthesis
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Hexanes / chemistry*
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Iodides / chemistry
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Oxidants / chemistry
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Pyrrolidines / chemical synthesis*
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Stereoisomerism
Substances
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Acids
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Bridged Bicyclo Compounds, Heterocyclic
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Esters
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Hexanes
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Iodides
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Oxidants
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Pyrrolidines