Abstract
A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / isolation & purification
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Anti-Bacterial Agents* / pharmacology
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Caribbean Region
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Glycolipids* / chemistry
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Glycolipids* / isolation & purification
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Glycolipids* / pharmacology
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / metabolism
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Plants / drug effects
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Porifera / chemistry*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / metabolism
Substances
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Anti-Bacterial Agents
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Glycolipids
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caminoside A
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caminoside B
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caminoside C
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caminoside D