High frequency of iatrogenic monozygotic twins with administration of clomiphene citrate and a change in chorionicity

Catherine Derom; Fernand Leroy; Robert Vlietinck; Jean-Pierre Fryns; Robert Derom

doi:10.1016/j.fertnstert.2005.08.034

High frequency of iatrogenic monozygotic twins with administration of clomiphene citrate and a change in chorionicity

Fertil Steril. 2006 Mar;85(3):755-7. doi: 10.1016/j.fertnstert.2005.08.034.

Authors

Catherine Derom¹, Fernand Leroy, Robert Vlietinck, Jean-Pierre Fryns, Robert Derom

Affiliation

¹ Center of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium. [email protected]

PMID: 16500356
DOI: 10.1016/j.fertnstert.2005.08.034

Abstract

The data of the population-based, prospective survey of multiple births in East Flanders, Belgium, show that a greater proportion of monozygotic twins is observed with clomiphene citrate as sole treatment compared with other ovulatory drugs. Among iatrogenic monozygotic twins, the ratio of monochorionic versus dichorionic pairs is higher compared with spontaneous twins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chorion*
Clomiphene / therapeutic use*
Female
Fertility Agents, Female / therapeutic use*
Gonadotropins / therapeutic use
Humans
Pregnancy
Prospective Studies
Reproductive Techniques, Assisted
Triplets
Twins, Dizygotic
Twins, Monozygotic*

Substances

Fertility Agents, Female
Gonadotropins
Clomiphene