Abstract
We treated 17 patients with localized, nasal NK/T-cell lymphoma with two cycles of dose-intense CHOP (DI-CHOP) and early involved field radiation (IFRT). Sixteen out of 17 patients were evaluable for response. After two cycles of DICHOP, nine patients achieved complete remission (CR) (53%) and six had partial remissions (35%). After IFRT, 13 patients achieved CR (CR rate 76%; 95% CI, 56%-96%). The 3-year progression-free and overall survival rates were 56%, and 67%, respectively. This study shows that anthracycline-based chemotherapy seems to be ineffective in decreasing systemic failure even when administered at maximal dose intensity.
MeSH terms
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Adult
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Aged
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Anthracyclines / pharmacology
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Anthracyclines / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Drug Resistance, Neoplasm / drug effects*
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Female
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Humans
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Killer Cells, Natural / drug effects
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Killer Cells, Natural / pathology*
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Killer Cells, Natural / radiation effects
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Lymphoma, T-Cell / drug therapy*
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Lymphoma, T-Cell / mortality
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Lymphoma, T-Cell / pathology
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Lymphoma, T-Cell / radiotherapy*
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Male
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Middle Aged
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Nasopharyngeal Neoplasms / drug therapy*
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Nasopharyngeal Neoplasms / mortality
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Nasopharyngeal Neoplasms / radiotherapy*
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Prednisone / administration & dosage
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Survival Rate
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Vincristine / administration & dosage
Substances
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Anthracyclines
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone