Abstract
Overactive bladder is a common and distressing problem. Standard therapy is directed towards modifying the detrusor motor sensitivity and response via anticholinergic medication. Currently available medications are reviewed and alternative targets for treatment are presented.
MeSH terms
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Acetylcholine / metabolism
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Amines / pharmacology
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Amines / therapeutic use
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Animals
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Anticonvulsants / pharmacology
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Anticonvulsants / therapeutic use*
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Benzhydryl Compounds / pharmacology
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Benzhydryl Compounds / therapeutic use
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Cresols / pharmacology
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Cresols / therapeutic use
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Cyclohexanecarboxylic Acids / pharmacology
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Cyclohexanecarboxylic Acids / therapeutic use
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Drug Evaluation, Preclinical
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Gabapentin
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Humans
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Mandelic Acids / pharmacology
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Mandelic Acids / therapeutic use
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Muscarinic Antagonists / pharmacology
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Muscarinic Antagonists / therapeutic use*
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Muscle, Smooth / drug effects*
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Muscle, Smooth / innervation
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Muscle, Smooth / metabolism
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Phenylpropanolamine / pharmacology
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Phenylpropanolamine / therapeutic use
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Product Surveillance, Postmarketing
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Quinuclidines / pharmacology
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Quinuclidines / therapeutic use
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Randomized Controlled Trials as Topic
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Receptor, Muscarinic M3 / antagonists & inhibitors
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Receptor, Muscarinic M3 / metabolism
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Solifenacin Succinate
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Tetrahydroisoquinolines / pharmacology
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Tetrahydroisoquinolines / therapeutic use
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Tolterodine Tartrate
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Urinary Bladder / drug effects
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Urinary Bladder / innervation
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Urinary Bladder / metabolism
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Urinary Incontinence / drug therapy*
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gamma-Aminobutyric Acid / pharmacology
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gamma-Aminobutyric Acid / therapeutic use
Substances
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Amines
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Anticonvulsants
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Benzhydryl Compounds
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Cresols
-
Cyclohexanecarboxylic Acids
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Mandelic Acids
-
Muscarinic Antagonists
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Quinuclidines
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Receptor, Muscarinic M3
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Tetrahydroisoquinolines
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Phenylpropanolamine
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gamma-Aminobutyric Acid
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Tolterodine Tartrate
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Gabapentin
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oxybutynin
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Solifenacin Succinate
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Acetylcholine