Abstract
A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines. Symptoms resolved when systemic corticosteroids were administered. This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / administration & dosage
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Antiprotozoal Agents / adverse effects*
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Antiprotozoal Agents / therapeutic use
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Child
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Chorioretinitis / congenital*
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Chorioretinitis / drug therapy
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Chorioretinitis / parasitology
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Drug Hypersensitivity / etiology
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Drug Hypersensitivity / physiopathology*
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Drug Therapy, Combination
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Eosinophilia / etiology
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Female
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Humans
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Pyrimethamine / administration & dosage
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Pyrimethamine / therapeutic use
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Recurrence
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Severity of Illness Index
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Sulfadiazine / administration & dosage
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Sulfadiazine / adverse effects*
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Sulfadiazine / therapeutic use
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Toxoplasma / drug effects
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Toxoplasmosis, Ocular / congenital*
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Toxoplasmosis, Ocular / drug therapy
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Toxoplasmosis, Ocular / parasitology
Substances
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Antiprotozoal Agents
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Sulfadiazine
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Pyrimethamine